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ea0016oc5.9 | Reproduction | ECE2008

Cognitive disabilities in the novel object task of male mice carrying a supernumerary X chromosome (41, XX*Y)

Wistuba Joachim , Damm Oliver , Luetjens C Marc , Simoni Manuela , Nieschlag Eberhard , Lewejohann Lars

Introduction: Several numerical chromosome abberations are known in men. Of those the karyotype XXY (Klinefelter syndrome KS) is the most common chromosomal disorder with a prevalence of about one in 500 live-born males. KS is associated with hypogonadism and is suspected to cause variable physical and cognitive abnormalities. As a supernumerary X chromosome is also associated with infertility, sound animal models for KS are difficult to obtain.Methods: ...

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ea0041ep711 | Male Reproduction | ECE2016

Altered testicular vascularization and impaired blood supply in the 41,XX^Y* mouse model for Klinefelter syndrome

Brand Cristin , Damm Oliver S , Warmeling Ann-Sophie , Sandhowe-Klaverkamp Reinhild , Werler Steffi , Koerner Katharina , Stypmann Joerg , Kuhlmann Michael , Holtmeier Richard , Zitzmann Michael , Tuettelmann Frank , Gromoll Joerg , Wistuba Joachim

Intratesticular testosterone levels in Klinefelter syndrome (KS) are comparable to controls and Leydig cell function was proven to be normal at least in vitro, testicular vascularization changes came into focus as a potential factor contributing to hypogonadism. We performed enhanced ultrasound based analysis of the testicular blood support in our 41,XXY* mice. Adult male 41,XXY* (n=5) and control mice (n=6) underwent ultrasound...

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Endocrine Abstracts

Cognitive disabilities in the novel object task of male mice carrying a supernumerary X chromosome (41, XX*Y)

Altered testicular vascularization and impaired blood supply in the 41,XX^Y* mouse model for Klinefelter syndrome

BiosciAbstracts

Endocrine Abstracts

Cognitive disabilities in the novel object task of male mice carrying a supernumerary X chromosome (41, XX*Y)

Altered testicular vascularization and impaired blood supply in the 41,XXY* mouse model for Klinefelter syndrome

BiosciAbstracts

Altered testicular vascularization and impaired blood supply in the 41,XX^Y* mouse model for Klinefelter syndrome